Results
| PMID | 23850516 |
| Gene Name | MUC16 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 710 |
| Population details | 710 (299 premenopausal women who underwent laparoscopic surgery, 197 patients with moderate to severe endometriosis, 102 patients with benign tumor, 112 healthy subjects) |
| Sex | Female |
| Associated genes | CA 125 |
| Other associated phenotypes |
Endometriosis |
|
J Minim Invasive Gynecol. 2015 Mar-Apr;22(3):373-7. doi: Yang, Hua| Zhu, Lan| Wang, Shu| Lang, Jinghe| Xu, Tao Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China.| Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China. STUDY OBJECTIVE: To investigate whether the combined value of the platelet-lymphocyte ratio (PLR) and serum cancer antigen 125 (CA 125) can be used in diagnosing moderate to severe endometriosis. DESIGN: A retrospective study (Canadian Task Force classification II-2). SETTING: A single center (Department of Obstetrics and Gynecology, Physical Examination Center of Peking Union Medical College Hospital, Beijing, China). PATIENTS: Two hundred ninety-nine premenopausal women who underwent laparoscopic surgery, 197 patients with moderate to severe endometriosis, 102 patients with benign tumor, and 112 healthy subjects. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Analyses were performed using 1-way analysis of variance and receiver operating characteristic (ROC) curves. RESULTS: The mean absolute value of serum CA 125, PLR, and the combination values were significantly increased for patients in the moderate to severe endometriosis group (p = .000, p = .004, p = .009, respectively). The area under the curve (AUC) for CA 125 was 0.943 (95% confidence interval [CI], 0.918-0.967) with a sensitivity and specificity of 71.6% and 99.1%, respectively. The AUC for PLR was 0.587 (95% CI, 0.520-0.653) with a sensitivity of 65.0%, a specificity of 51.8%, and a cutoff value at 117.16. The combination, which was calculated by multiplying CA 125 levels by the PLR, with an AUC of 0.929 (95% CI, 0.900-0.958) and a cutoff value of 2812.40, showed the highest sensitivity of 90.4% but a lower specificity of 84.8%. CONCLUSION: Serum CA 125 is better than the PLR and the combination biomarkers in diagnosing moderate to severe endometriosis. Mesh Terms: Adult| Biomarkers/blood| CA-125 Antigen/*blood| China| Endometriosis/*blood/diagnosis| Female| Humans| Leiomyoma/*blood/diagnosis| Lymphocyte Count| Lymphocytes/*metabolism| Neutrophils/*metabolism| Platelet Count| Predictive Value of Tests| |
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